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wnt_hedgehog_notch_compound_library
/library/wnt_hedgehog_notch_compound_library
Wnt/Hedgehog/Notch 通路化合物库
Wnt/Hedgehog/Notch Compound Library
产品编号: L4300

Wnt 信号通路在动物中高度保守,在动物胚胎发育中发挥重要作用,其异常表达或激活能引起肿瘤。Hedgehog(Hh)信号通路在多种生理过程中起着关键作用,如胚胎发育及维持成人机体内环境稳定等。近年来多项研究表明在皮肤基底细胞癌、髓母细胞瘤、肺癌、消化道肿瘤、乳腺癌等多种肿瘤组织中都存在Hh 信号通路的异常激活,并与肿瘤的增殖分化、细胞凋亡、血管新生、侵袭转移等密切相关,提示异常激活的Hh 信号通路在肿瘤发生、发展过程中其重要作用,阻断肿瘤中Hh 信号通路将为人类肿瘤的治疗提供一个新的有效途径。Notch 信号通路广泛存在于脊椎和无脊椎动物,在进化上高度保守,通过相邻细胞之间的相互作用调节细胞、组织、器官的分化和发育。 目前Notch 信号异常已经与多种疾病联系起来,包括肿瘤、CADASIL 综合征、Alagille 综合征、脊椎肋骨发育不全等。

TargetMol 可以为您提供多个Wnt & Hedgehog & Notch 信号通路研究相关的优质产品,为您的相关信号通路研究及相关药物筛选提供有效工具。

陶术生物的所有产品和服务仅用于科学研究,我们不为任何个人用途提供产品和服务。
产品编号:L4300
  • 237个Wnt & Hedgehog & Notch靶点相关的生物活性小分子化合物的特有集合,用于相关通路的研究及药物的筛选,可用于高通量、高内涵筛选。
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。
化合物库定制
我们的化合物库可以灵活定制!了解更多
化合物库咨询
化合物库组成
Wnt/beta-catenin (48)
GSK-3 (40)
Autophagy (28)
Casein Kinase (26)
Apoptosis (26)
Hedgehog/Smoothened (22)
Gamma-secretase (17)
CDK (17)
Smo (16)
ROCK (15)
c-Myc (12)
CaMK (11)
PARP (7)
Src (6)
PKC (6)
PKA (5)
Porcupine (5)
Antifungal (4)
Phospholipase (4)
p38 MAPK (3)
Calcium Channel (3)
Aurora Kinase (3)
Beta Amyloid (3)
S6 Kinase (3)
HIV Protease (2)
PI3K (2)
JNK (2)
Mitophagy (2)
Parasite (2)
ERK (2)
Immunology/Inflammation related (2)
JAK (2)
Lipoxygenase (2)
Antibacterial (2)
NF-κB (2)
MEK (2)
SGK (2)
FLT (2)
Antibiotic (2)
MLK (2)
ATPase (1)
DNA-PK (1)
Histone Methyltransferase (1)
Estrogen/progestogen Receptor (1)
Others (1)
Ferroptosis (1)
c-Met/HGFR (1)
DYRK (1)
Histamine Receptor (1)
Phosphatase (1)
Virus Protease (1)
ABC (1)
Estrogen Receptor/ERR (1)
PPAR (1)
Tyrosine Kinases (1)
Pim (1)
Serine/threonin kinase (1)
VEGFR (1)
Glucocorticoid Receptor (1)
RIP kinase (1)
Bcr-Abl (1)
PDE (1)
GRK (1)
Drug Metabolite (1)
P2X Receptor (1)
DNA Alkylation (1)
PDGFR (1)
HSV (1)
MMP (1)
Chk (1)
Epigenetic Reader Domain (1)
IGF-1R (1)
DNA (1)
TGF-beta/Smad (1)
MAPK (1)
LRRK2 (1)
Trk receptor (1)
ALK (1)
MELK (1)
Methionine Adenosyltransferase (MAT) (1)
STAT (1)
HDAC (1)
KLF (1)
PI4K (1)
GABA Receptor (1)
P450 (1)
FGFR (1)
Potassium Channel (1)
Syk (1)
Sodium Channel (1)
cholecystokinin (1)
Microtubule Associated (1)
Kinesin (1)
化合物库信息示例
Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE