High diversity: applied Daylight fingerprints and Tanimoto similarity calculations based on the Tanimoto coefficient of 0.65 to produce an exceptionally diverse commercial library providing the best opportunity to find hits. High hit probability: compounds are drug-like, conforming to Lipinski’s Rule of 5 and additional filters. Reliability: compounds within the library have been screened to remove any inappropriate chemical structures, avoiding “false hits” using our false positives exclusion criteria. The pre-plated Maybridge HitCreator collection consists of 14,000 screening compounds, derived from a rigorous analysis of more than 500,000 commercially available screening compounds. These compounds have been selected using a clustering algorithm, based on standard Daylight fingerprints and Tanimoto similarity.