免疫/炎症分子化合物库

Immunology/Inflammation Compound Library

产品编号： L4700

当某些触发因素引起免疫系统功能紊乱，使其不能区分正常组织和病原，开始攻击破坏自身正常组织时，就会发生自身免疫性疾病，受累部位包括血管、结缔组织、关节和皮肤等。随着19-20世纪的化学进展，开发了非甾体抗炎药（NSAIDs），尽管有效治疗炎性疾病，但NSAID 具有一些不良作用，例如溃疡，肾损伤和胃肠道出血。后来虽然被描述为抗肿瘤介质，但肿瘤坏死因子-α（TNF）通常被认为是主要的促炎细胞因子。它在炎性疾病的发病机制中起关键作用，因此，抗TNF 治疗已成为治疗自身免疫性疾病的主要方法。随着基础研究的快速进展，许多与自身免疫性疾病相关的信号传导途径及相关蛋白陆续被发现，这些蛋白是潜在治疗免疫性疾病的药物靶点，例如，很多小分子化合物或基于大环的药物具有抑制免疫蛋白酶体、抑制核输出蛋白、抑制 NF-kB 和肿瘤坏死因子-α（TNF）的活性，这些化合物有可能发展成用于治疗自身免疫疾病和慢性炎症疾病的药物。 TargetMol 免疫/炎症分子化合物库包含了4940 个抗炎活性化合物，用于抗免疫疾病药物高通量筛选，确认药物靶点以及其他医药研发和科研领域。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品编号：L4700

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

4940种具有抗炎症活性的化合物的特有集合，可用于高通量筛选和高内涵筛选；
部分化合物已经得到FDA批准上市；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Histamine Receptor (179)

COX (178)

EGFR (165)

PDE (139)

JAK (99)

HIV Protease (96)

Antiviral (87)

Prostaglandin Receptor (87)

Raf (74)

NF-κB (72)

Reactive Oxygen Species (70)

5-HT Receptor (66)

Antifungal (63)

p38 MAPK (58)

Parasite (58)

Adrenergic Receptor (56)

ERK (54)

BTK (54)

TLR (54)

STAT (51)

CDK (48)

Ras (48)

CCR (47)

MAPK (47)

IL Receptor (46)

Kras (46)

AMPK (46)

AChR (46)

TNF (44)

Glucocorticoid Receptor (43)

DNA/RNA Synthesis (41)

VEGFR (40)

ROS (40)

HCV Protease (39)

CXCR (39)

MEK (39)

HER (39)

FLT (38)

PI3K (37)

SARS-CoV (37)

IκB/IKK (37)

GSK-3 (36)

Tyrosine Kinases (36)

Src (35)

Endogenous Metabolite (33)

Dopamine Receptor (31)

RIP kinase (31)

Interleukin (31)

Ferroptosis (30)

Potassium Channel (30)

Calcium Channel (29)

Reverse Transcriptase (29)

NOS (28)

Influenza Virus (28)

GPR (28)

S6 Kinase (28)

PPAR (27)

Dehydrogenase (26)

Lipoxygenase (26)

JNK (25)

Nrf2 (25)

P450 (25)

NOD (24)

PDGFR (23)

Antioxidant (22)

STING (22)

FGFR (22)

Complement System (22)

IRAK (21)

HBV (20)

Pim (20)

NO Synthase (20)

S1P Receptor (20)

LTR (19)

mTOR (19)

Phospholipase (19)

Syk (19)

AhR (19)

TRP/TRPV Channel (18)

Aryl Hydrocarbon Receptor (18)

Aurora Kinase (18)

Epigenetic Reader Domain (18)

Akt (18)

c-Kit (18)

PD-1/PD-L1 (18)

LPL Receptor (17)

Antifection (17)

Proteasome (16)

Histone Methyltransferase (16)

Estrogen/progestogen Receptor (16)

Virus Protease (16)

Rho (16)

Immunology/Inflammation related (16)

Sodium Channel (16)

Adenosine Receptor (15)

Topoisomerase (15)

Bcr-Abl (15)

MMP (15)

HDAC (15)

Cannabinoid Receptor (15)

RAAS (14)

Phosphatase (14)

MRP (14)

Serine Protease (14)

PKC (14)

Norepinephrine (14)

Mitophagy (13)

Wnt/beta-catenin (13)

HSV (13)

Casein Kinase (13)

Integrin (12)

Caspase (12)

ribosome (12)

Mitochondrial Metabolism (11)

IGF-1R (11)

TGF-beta/Smad (11)

PGE Synthase (11)

Sirtuin (11)

ALK (11)

c-Fms (11)

c-RET (11)

PKA (10)

ROCK (10)

Trk receptor (10)

Beta Amyloid (10)

NADPH-oxidase (10)

Thrombin (10)

HIF/HIF Prolyl-Hydroxylase (10)

NOD-like Receptor (NLR) (10)

NADPH (9)

Leukotriene Receptor (9)

MAO (9)

Drug Metabolite (9)

Opioid Receptor (9)

MNK (9)

MLK (9)

Proton pump (8)

P2Y Receptor (8)

IFNAR (8)

Estrogen Receptor/ERR (8)

P2X Receptor (8)

HSP (8)

Microtubule Associated (8)

ROS Kinase (8)

Glutathione Peroxidase (7)

Nucleoside Antimetabolite/Analog (7)

Cysteine Protease (7)

FAAH (7)

DUB (7)

Indoleamine 2,3-Dioxygenase (IDO) (7)

ASK (7)

GABA Receptor (7)

Sigma receptor (7)

ATPase (6)

DNA-PK (6)

ADC Cytotoxin (6)

c-Met/HGFR (6)

GTPase (6)

Progesterone Receptor (6)

PARP (6)

Serotonin Transporter (6)

SIK (6)

FLAP (6)

E1/E2/E3 Enzyme (6)

NMDAR (6)

Chk (6)

Epoxide Hydrolase (6)

CaMK (6)

DNA (6)

AChE (6)

cGAS (6)

Retinoid Receptor (6)

SGK (6)

Protease-activated Receptor (6)

Chloride channel (5)

Carbonic Anhydrase (5)

MALT (5)

DHFR (5)

ROR (5)

MyD88 (5)

PERK (5)

TOPK (5)

Galectin (5)

Antifolate (5)

FXR (5)

CSF-1R (5)

DNA gyrase (5)

BCL (5)

DPP-4 (5)

GluR (5)

CD73 (5)

RSV (5)

LPA Receptor (5)

HIF (5)

DYRK (4)

Cell wall (4)

Histone Demethylase (4)

c-Myc (4)

IDO (4)

iGluR (4)

Annexin A (4)

Hedgehog/Smoothened (4)

Xanthine Oxidase (4)

cAMP (4)

Aminopeptidase (4)

AIM2 (4)

Histone Acetyltransferase (4)

Pyroptosis (4)

ATM/ATR (4)

Neurokinin receptor (4)

Tyrosinase (4)

CAT (3)

Transferase (3)

CD38 (3)

DNA Alkylator/Crosslinker (3)

ABC (3)

Serine/threonin kinase (3)

Fatty Acid Synthase (3)

DNA Alkylation (3)

Bradykinin Receptor (3)

Thrombopoietin Receptor (3)

Telomerase (3)

P-gp (3)

LRRK2 (3)

Free radical scavengers (3)

GPCR19 (3)

Ephrin Receptor (3)

Acetyl-CoA Carboxylase (3)

KLF (3)

Adenosine deaminase (3)

Discoidin Domain Receptor (DDR) (3)

Platelet aggregation (3)

cholecystokinin (3)

FAK (3)

p53 (3)

EBI2/GPR183 (2)

Arginase (2)

Reductase (2)

Arrestin (2)

Lipase (2)

gp120/CD4 (2)

Tie-2 (2)

Factor Xa (2)

Glutaminase (2)

Gamma-secretase (2)

Smo (2)

Endothelin Receptor (2)

ACK (2)

Androgen Receptor (2)

SGLT (2)

BCRP (2)

Acyltransferase (2)

MRGPR (2)

PAI-1 (2)

MELK (2)

Hippo pathway (2)

Protease (2)

PI4K (2)

PDK (2)

Hydroxylase (2)

Gap Junction Protein (2)

DNA Methyltransferase (2)

HMG-CoA Reductase (2)

PKM (2)

Melanin-concentrating Hormone Receptor (MCHR) (1)

Apelin receptor (1)

advanced glycation end products (1)

Mdm2 (1)

Taste receptor (1)

Adenylyl cyclase (1)

GSNOR (1)

NPC1L1 (1)

Monocarboxylate transporter (1)

Dynamin (1)

CRM1 (1)

Amino Acids and Derivatives (1)

DprE1 (1)

YAP (1)

Na+/Ca2+ Exchanger (1)

RAR/RXR (1)

Necroptosis (1)

VDA (1)

Melatonin Receptor (1)

N-Acetylglucosaminyltransferase (1)

GNRH Receptor (1)

Liver X Receptor (1)

Neurotensin Receptor (1)

LIM Kinase (1)

Glucokinase (1)

PYK2 (1)

RANKL/RANK (1)

UGT (1)

PAFR (1)

Haspin Kinase (1)

PACAP (1)

MT Receptor (1)

Glucagon Receptor (1)

AAK1 (AP2 associated kinase 1) (1)

GlyT (1)

Na-K-Cl cotransporter (1)

Glucosidase (1)

Monoamine Transporter (1)

Anion Exchanger (1)

Guanylate cyclase (1)

Integrase (1)

MAGL (1)

Neuropeptide Y Receptor (1)

PAK (1)

Vasopressin Receptor (1)

PTEN (1)

Somatostatin (1)

OX Receptor (1)

ATP Citrate Lyase (1)

Lipid (1)

OXPHOS (1)

Glutathione reductase (1)

transporter (1)

CRFR (1)

Methionine Adenosyltransferase (MAT) (1)

Neprilysin (1)

GST (1)

GPX (1)

CRISPR/Cas9 (1)

Oxytocin Receptor (1)

GHSR (1)

RXFP receptor (1)

PLK (1)

CGRP Receptor (1)

DAPK (1)

Anti-infection (1)

BMI-1 (1)

TAM Receptor (1)

Imidazoline Receptor (1)

Kinesin (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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