含氟化合物库 | L5100 | 陶术生物

含氟化合物库

Fluorochemical Library

产品编号： L5100

氟原子的引入常常导致有机化合物产生独特的物理、化学性质和生物活性，因而有机氟化物被用于从药物化学到材料科学等多个领域中。有机氟化物在医药工业中有非常重要的应用。目前上市的新药中，每年大约有15-20%都是有机氟化合物。在含氟的药物分子中，每个引入的氟原子或含氟基团都有其特定的目的。总体上看，氟原子对药物分子的影响主要有：

氟的引入不使分子发生明显的立体构型变化，但使分子的电子性质产生很大的改变。氟的引入对于分子的亲脂性是有利的，具有更好的生物穿透性。

通过向底物引入氟原子，可以选择性地阻断一些不希望发生的代谢途径，让药物前体只转化为希望的生物活性物质，增加药物的生物利用度，稳定代谢。

基于氢原子与氟原子在体积上的相似性和在反应性上的根本差别而发挥作用。5-氟尿嘧啶是此类抑制剂中比较典型的一个例子。

因此，含氟药物的应用研究越来越深入。TargetMol 含氟化合物库是开发新的抗癌药物、抗肿瘤药物、抗病毒药物、消炎药物等的有效工具。在现代农作物保护方面，含氟农用化学品已广泛用作除草剂、杀虫剂以及杀菌剂等。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品编号：L5100

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

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产品描述

2684个含氟化合物的独特集合，可用于高通量筛选和高内涵筛选；
通过前期临床研究和临床实验，生物活性和安全性已经得到验证；
其中一些含氟化合物已得到FDA批准上市；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR和HPLC检测技术保证产品高纯度；
所有化合物现货供应。

化合物库定制

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化合物库组成

Apoptosis (165)

Autophagy (117)

5-HT Receptor (77)

Antibacterial (73)

VEGFR (63)

EGFR (61)

Antibiotic (61)

Dehydrogenase (57)

PI3K (50)

DNA/RNA Synthesis (50)

Dopamine Receptor (49)

Raf (48)

Antifungal (43)

Sodium Channel (42)

CDK (41)

p38 MAPK (36)

COX (36)

Potassium Channel (36)

FLT (36)

HIV Protease (35)

c-Met/HGFR (35)

TRP/TRPV Channel (35)

PDGFR (35)

GluR (35)

Parasite (33)

Calcium Channel (33)

PDE (33)

c-Kit (33)

Kras (32)

Bcr-Abl (31)

Androgen Receptor (30)

Src (29)

Glucocorticoid Receptor (29)

JAK (29)

Epigenetic Reader Domain (29)

GPR (29)

Prostaglandin Receptor (28)

Histone Methyltransferase (24)

GABA Receptor (24)

HCV Protease (23)

PARP (22)

Adrenergic Receptor (22)

Phospholipase (22)

MEK (22)

AChR (22)

BTK (21)

Aurora Kinase (21)

FGFR (21)

Nucleoside Antimetabolite/Analog (20)

SARS-CoV (20)

CCR (19)

mTOR (19)

HER (19)

PPAR (18)

Gamma-secretase (18)

P450 (18)

MAPK (17)

HBV (16)

Topoisomerase (16)

c-RET (16)

TAM Receptor (16)

Histamine Receptor (15)

ERK (15)

HDAC (15)

Microtubule Associated (15)

Estrogen/progestogen Receptor (14)

Tyrosine Kinases (14)

iGluR (14)

DUB (14)

Antiviral (14)

Trk receptor (14)

ROR (13)

Phosphatase (13)

Wnt/beta-catenin (13)

Akt (13)

S6 Kinase (13)

Proteasome (12)

Reductase (12)

GSK-3 (12)

NMDAR (12)

ALK (12)

Casein Kinase (12)

STAT (12)

YAP (11)

Virus Protease (11)

Cysteine Protease (11)

Caspase (11)

Guanylate cyclase (11)

IL Receptor (11)

Influenza Virus (11)

Ras (11)

CFTR (11)

Adenosine Receptor (10)

PKC (10)

ROCK (10)

Glucagon Receptor (10)

CXCR (10)

Histone Acetyltransferase (10)

IκB/IKK (10)

NF-κB (10)

PLK (10)

Cannabinoid Receptor (10)

Discoidin Domain Receptor (DDR) (10)

S1P Receptor (10)

Mdm2 (9)

Proton pump (9)

LPL Receptor (9)

CETP (9)

Estrogen Receptor/ERR (9)

MAO (9)

E1/E2/E3 Enzyme (9)

ROS (9)

Isocitrate Dehydrogenase (IDH) (9)

BCL (9)

Epoxide Hydrolase (9)

Indoleamine 2,3-Dioxygenase (IDO) (9)

TGF-beta/Smad (9)

HSP (9)

STING (9)

HIF (9)

TNF (9)

Neurokinin receptor (9)

FAK (9)

ROS Kinase (9)

Ferroptosis (8)

BACE (8)

PERK (8)

Mitophagy (8)

Rho (8)

Liver X Receptor (8)

RIP kinase (8)

P2X Receptor (8)

DPP-4 (8)

Hedgehog/Smoothened (8)

Lipoxygenase (8)

transporter (8)

Beta Amyloid (8)

AMPK (8)

Chloride channel (7)

Serotonin Transporter (7)

IDO (7)

Opioid Receptor (7)

FAAH (7)

OX Receptor (7)

Interleukin (7)

Reverse Transcriptase (7)

Hydroxylase (7)

HMG-CoA Reductase (7)

p53 (7)

DNA-PK (6)

ADC Cytotoxin (6)

P2Y Receptor (6)

Lipase (6)

Serine Protease (6)

Aryl Hydrocarbon Receptor (6)

DNA gyrase (6)

Neuropeptide Y Receptor (6)

Stearoyl-CoA Desaturase (SCD) (6)

LRRK2 (6)

Ephrin Receptor (6)

Nrf2 (6)

ATM/ATR (6)

c-Fms (6)

IRAK (6)

HIF/HIF Prolyl-Hydroxylase (6)

AhR (6)

ATPase (5)

Carbonic Anhydrase (5)

Transferase (5)

CRM1 (5)

Tie-2 (5)

GTPase (5)

c-Myc (5)

GNRH Receptor (5)

PKA (5)

Pim (5)

Glucokinase (5)

CSF-1R (5)

GRK (5)

Drug Metabolite (5)

Mitochondrial Metabolism (5)

Smo (5)

Reactive Oxygen Species (5)

Chk (5)

Beta-Secretase (5)

Acyltransferase (5)

TLR (5)

PI4K (5)

Syk (5)

Sigma receptor (5)

Monoamine Oxidase (5)

Kinesin (5)

Melanin-concentrating Hormone Receptor (MCHR) (4)

NOS (4)

Integrin (4)

DYRK (4)

Serine/threonin kinase (4)

IAP (4)

GlyT (4)

Fatty Acid Synthase (4)

PAK (4)

HSV (4)

MMP (4)

IGF-1R (4)

Norepinephrine (4)

P-gp (4)

RSV (4)

Retinoid Receptor (4)

Endogenous Metabolite (4)

PDK (4)

DNA Methyltransferase (4)

Antioxidant (3)

NADPH (3)

Factor Xa (3)

LIM Kinase (3)

FXR (3)

Leukotriene Receptor (3)

Neurotensin Receptor (3)

IRE1 (3)

Myosin (3)

DNA Alkylation (3)

Somatostatin (3)

OXPHOS (3)

PGE Synthase (3)

PSMA (3)

Sirtuin (3)

ASK (3)

Methionine Adenosyltransferase (MAT) (3)

GHSR (3)

Complement System (3)

NOD (3)

Protease-activated Receptor (3)

Monocarboxylate transporter (2)

MALT (2)

DprE1 (2)

Sodium-dependent phosphate transporter (2)

IFNAR (2)

Arrestin (2)

RAR/RXR (2)

Histone Demethylase (2)

RAAS (2)

JNK (2)

Galectin (2)

CaSR (2)

MRP (2)

PYK2 (2)

NAMPT (2)

Glutaminase (2)

SIK (2)

Annexin A (2)

Phosphorylase (2)

Antifection (2)

Integrase (2)

Vasopressin Receptor (2)

Xanthine Oxidase (2)

ACK (2)

KSP (2)

cAMP (2)

Telomerase (2)

SGLT (2)

MRGPR (2)

Porcupine (2)

CRFR (2)

GPX (2)

LPA Receptor (2)

CGRP Receptor (2)

SGK (2)

NOD-like Receptor (NLR) (2)

Thyroid hormone receptor(THR) (1)

Adenylyl cyclase (1)

PROTACs (1)

NPC1L1 (1)

DHFR (1)

NEDD8 (1)

Amino Acids and Derivatives (1)

LTR (1)

Na+/Ca2+ Exchanger (1)

Glutathione Peroxidase (1)

Progesterone Receptor (1)

OCT (1)

N-Acetylglucosaminyltransferase (1)

VDAC (1)

Hck (1)

FOXO1 (1)

RANKL/RANK (1)

Immunology/Inflammation related (1)

UGT (1)

MTH1 (1)

LDL (1)

AAK1 (AP2 associated kinase 1) (1)

Monoamine Transporter (1)

Anion Exchanger (1)

Bombesin Receptor (1)

Bradykinin Receptor (1)

PTEN (1)

CaMK (1)

DNA (1)

ATP Citrate Lyase (1)

BCRP (1)

Survivin (1)

MNK (1)

OAT (1)

CD73 (1)

AIM2 (1)

GluCls (1)

PAI-1 (1)

MELK (1)

Acetyl-CoA Carboxylase (1)

Protease (1)

Aromatase (1)

Melanocortin Receptor (1)

KLF (1)

Aquaporin (1)

RXFP receptor (1)

Anti-infection (1)

BMI-1 (1)

Tyrosinase (1)

Thrombin (1)

lysosomal autophagy (1)

MLK (1)

PD-1/PD-L1 (1)

NO Synthase (1)

PKM (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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