细胞周期化合物库 | L8100 | 陶术生物

细胞周期化合物库

Cell Cycle Compound Library

产品编号： L8100

细胞周期（cell cycle）是指增殖细胞从一次分裂结束到下一次分裂结束所经历的全过程，分为间期与分裂期两个阶段，间期又分为DNA 合成前期（G1期）、DNA 合成期（S 期）与DNA 合成后期（G2期），分裂期也称为M 期。细胞周期相关化合物依赖于不同的作用机制来调控细胞周期的正常进展。这些化合物中的一些干扰CDK /细胞周期蛋白复合物，使细胞停留在G2 / M 期边界，还有一些化合物影响CaMKII 磷酸化，诱导G1期停滞。其它作用机制包括干扰RNA 功能和抑制蛋白质合成。许多这些化合物由于它们中断细胞周期而诱导细胞凋亡，可用于抗肿瘤药的筛选。 TargetMol 细胞周期化合物库是945 个细胞周期相关的小分子化合物的独特集合，用于细胞周期相关的研究及药物的筛选，可用于高通量、高内涵筛选。

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产品编号：L8100

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

945种细胞周期相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
靶点包括CDK、ROCK、Aurora Kinase、ATM/ATR、DNA-PK、DNA/RNA Synthesis等；
是研究细胞周期及相关疾病的有效工具，例如癌症、心血管疾病、炎症、神经退行性疾病等；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

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化合物库组成

Apoptosis (135)

Nucleoside Antimetabolite/Analog (76)

Aurora Kinase (54)

Autophagy (52)

ROCK (50)

DUB (44)

Serine/threonin kinase (39)

PLK (29)

GSK-3 (27)

Rho (26)

Chk (25)

Antibacterial (23)

FLT (22)

DHFR (21)

DYRK (20)

Antibiotic (20)

PD-1/PD-L1 (20)

Ras (19)

PKA (17)

PKC (17)

Src (16)

VEGFR (16)

c-Myc (15)

Antifolate (14)

IRE1 (14)

Dehydrogenase (12)

ERK (12)

JAK (11)

HSV (11)

Akt (11)

SARS-CoV (11)

HIV Protease (10)

PDGFR (10)

Casein Kinase (10)

S6 Kinase (10)

LIM Kinase (9)

Bcr-Abl (9)

Epigenetic Reader Domain (9)

Topoisomerase (8)

Wee1 (8)

Influenza Virus (8)

Endogenous Metabolite (8)

c-RET (8)

FGFR (8)

PROTACs (7)

Parasite (7)

APC (7)

DNA Alkylator/Crosslinker (6)

MAPK (6)

MEK (6)

c-Kit (6)

HCV Protease (5)

Virus Protease (5)

Pim (5)

Trk receptor (5)

SGK (5)

BMI-1 (5)

ADC Cytotoxin (4)

PI3K (4)

Serine Protease (4)

MTH1 (4)

KSP (4)

EGFR (4)

Antiviral (4)

LRRK2 (4)

p38 MAPK (3)

c-Met/HGFR (3)

Histone Demethylase (3)

JNK (3)

HBV (3)

Tyrosine Kinases (3)

PARP (3)

Caspase (3)

Calcium Channel (3)

Haspin Kinase (3)

AAK1 (AP2 associated kinase 1) (3)

BCL (3)

TGF-beta/Smad (3)

IκB/IKK (3)

ATM/ATR (3)

Carboxypeptidase (3)

Reverse Transcriptase (3)

STAT (3)

PDK (3)

NF-κB (3)

cholecystokinin (3)

FAK (3)

Kinesin (3)

Histone Methyltransferase (2)

DNA-PK (2)

Antifungal (2)

Mitophagy (2)

PYK2 (2)

Raf (2)

GRK (2)

Drug Metabolite (2)

DNA gyrase (2)

Mitochondrial Metabolism (2)

Antifection (2)

Reactive Oxygen Species (2)

DNA Alkylation (2)

MMP (2)

IGF-1R (2)

DNA (2)

Interleukin (2)

Telomerase (2)

HSP (2)

c-Fms (2)

KLF (2)

AMPK (2)

DNA Methyltransferase (2)

IRAK (2)

TAM Receptor (2)

Microtubule Associated (2)

Carbonic Anhydrase (1)

Dopamine Receptor (1)

Amino Acids and Derivatives (1)

YAP (1)

Ferroptosis (1)

Adenosine Receptor (1)

BACE (1)

PERK (1)

Histamine Receptor (1)

Tie-2 (1)

TOPK (1)

Wnt/beta-catenin (1)

cell cycle arrest (1)

Cysteine Protease (1)

TRP/TRPV Channel (1)

Aryl Hydrocarbon Receptor (1)

MAO (1)

Myosin (1)

E1/E2/E3 Enzyme (1)

RIP kinase (1)

BTK (1)

Molecular Glues (1)

IL Receptor (1)

Lipoxygenase (1)

CaMK (1)

COX (1)

mTOR (1)

P-gp (1)

MNK (1)

Prostaglandin Receptor (1)

Free radical scavengers (1)

Histone Acetyltransferase (1)

PAI-1 (1)

MELK (1)

RSV (1)

Beta Amyloid (1)

CRISPR/Cas9 (1)

GPR (1)

Potassium Channel (1)

AChR (1)

DAPK (1)

Syk (1)

Sodium Channel (1)

HIF/HIF Prolyl-Hydroxylase (1)

NOD-like Receptor (NLR) (1)

p53 (1)

MLK (1)

HER (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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