已知活性化合物库 | L4010 | 陶术生物

已知活性化合物库

Bioactive Compounds Library Max

产品编号： L4010

已知活性库是 26102 个具有生物活性，能引起细胞、组织甚至个体生物学反应的化合物的集合。包括了正在进行临床前研究的药物分子，临床期的药物分子和已经上市的药物。靶点明确，信息全面，非常适合完成药物功能重定位、小分子诱导细胞分化以及机制研究中蛋白靶点确认等科研工作。

由于活性明确，靶点已知，很多科学家会从已知活性库中选择可以用于细胞诱导分化的小分子；通过单一或几个小分子的联合作用，筛选出能将各种体细胞诱导成为诱导多能干细胞，神经前体细胞，心肌细胞等的分子；甚至还有使用小分子组合在体内完成诱导分化的成功尝试。

已知活性库是对经典已知活性库的补充，添加了 TargetMol 特有，新颖的化合物（Part B），所有化合物靶点明确，且都进行过细胞水平活性测试，比上市药物库结构更为新颖，比类药化合物库更易发现活性化合物。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品编号：L4010

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

26102个已知活性化合物的集合，可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认；
所有化合物都有相应的靶点信息的描述，活性研究更有保障和依据；
是老药新用、细胞诱导靶点筛选的有效工具；
涵盖多个疾病研究领域，如癌症、代谢、免疫和心血管系统等；
详细的说明书，化合物结构、靶点信息、活性描述等；
结构多样，药效显著，可渗透细胞；

化合物库定制

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化合物库组成

EGFR (199)

Histamine Receptor (192)

Sodium Channel (185)

PDE (184)

Dehydrogenase (183)

Cytochromes P450 (182)

Epigenetic Reader Domain (181)

Reactive Oxygen Species (176)

GABA Receptor (175)

VEGFR (164)

GluR (150)

Histone Methyltransferase (149)

PPAR (144)

TRP/TRPV Channel (142)

Influenza Virus (141)

Microtubule Associated (136)

HDAC (127)

Phosphatase (126)

TNF (125)

GPR (124)

Cholinesterase (ChE) (118)

Wnt/beta-catenin (117)

JAK (117)

mTOR (117)

p38 MAPK (113)

Topoisomerase (113)

Akt (113)

SARS-CoV (113)

Prostaglandin Receptor (111)

Estrogen/progestogen Receptor (107)

Antiviral (107)

Src (106)

ERK (106)

RAAS (104)

PKC (104)

Adenosine Receptor (102)

FLT (102)

Ferroptosis (101)

Opioid Receptor (101)

IL Receptor (101)

HCV Protease (100)

STAT (100)

PARP (99)

NMDAR (99)

Estrogen Receptor/ERR (94)

PDGFR (93)

iGluR (92)

Nucleoside Antimetabolite/Analog (91)

MMP (91)

AMPK (89)

Caspase (88)

GSK-3 (86)

FGFR (85)

Bcl-2 Family (84)

Virus Protease (82)

NO Synthase (82)

Lipoxygenase (81)

Raf (80)

MAO (77)

Glucocorticoid Receptor (77)

Androgen Receptor (77)

TLR (76)

c-Kit (74)

c-Met/HGFR (73)

Cannabinoid Receptor (73)

ATPase (72)

HBV (72)

ROS (72)

HSP (72)

Beta Amyloid (72)

Phospholipase (72)

Bcr-Abl (71)

TGF-beta/Smad (68)

ALK (68)

Proteasome (67)

Mitochondrial Metabolism (66)

HSV (65)

Anti-infection (63)

Tyrosinase (63)

Sirtuin (62)

Drug Metabolite (61)

BTK (61)

Nrf2 (61)

ADC Cytotoxin (60)

Histone Demethylase (60)

MAPK (60)

DUB (58)

Integrin (57)

Antifection (57)

NOS (56)

JNK (56)

Aurora Kinase (56)

Ras (56)

HIF/HIF Prolyl-Hydroxylase (56)

PKA (54)

P-gp (54)

Kras (54)

Tyrosine Kinases (53)

ROCK (53)

HER (53)

Transferase (52)

Mitophagy (52)

E1/E2/E3 Enzyme (52)

CCR (52)

p53 (50)

Gamma-secretase (49)

IκB/IKK (49)

Monoamine Oxidase (48)

Carbonic Anhydrase (47)

Immunology/Inflammation related (47)

Interleukin (47)

Reverse Transcriptase (47)

MEK (47)

Casein Kinase (46)

HIF (46)

Neurokinin receptor (46)

Serotonin Transporter (44)

P2X Receptor (44)

CXCR (44)

Retinoid Receptor (44)

Reductase (43)

Cysteine Protease (43)

Norepinephrine (43)

Serine Protease (42)

Serine/threonin kinase (42)

IGF-1R (42)

S1P Receptor (42)

PROTACs (40)

Glucosidase (40)

DNA-PK (39)

FAK (39)

Hedgehog/Smoothened (38)

CaMK (38)

c-RET (38)

NOD (38)

LPL Receptor (36)

Trk receptor (36)

Histone Acetyltransferase (36)

RIP kinase (35)

TAM Receptor (35)

Sigma receptor (35)

Proton pump (33)

FAAH (33)

transporter (32)

S6 Kinase (32)

Chloride channel (31)

Progesterone Receptor (31)

Glucokinase (31)

Fatty Acid Synthase (31)

PLK (31)

Amino Acids and Derivatives (30)

PERK (30)

Acyltransferase (30)

ATM/ATR (30)

c-Fms (30)

ribosome (30)

Syk (30)

CFTR (30)

DPP-4 (29)

HMG-CoA Reductase (29)

Thrombin (29)

Mdm2 (28)

Neuropeptide Y Receptor (28)

Endothelin Receptor (28)

Protease-activated Receptor (28)

Chk (27)

DNA (27)

Thyroid hormone receptor(THR) (26)

NADPH (26)

Rho (26)

Pim (25)

Aryl Hydrocarbon Receptor (25)

Glucagon Receptor (25)

cAMP (25)

AhR (25)

Kinesin (25)

DNA Alkylator/Crosslinker (24)

Smo (24)

Complement System (24)

DNA Methyltransferase (24)

IRAK (24)

ROR (23)

P2Y Receptor (23)

LTR (23)

BACE (23)

Lipase (23)

Factor Xa (23)

Leukotriene Receptor (23)

STING (23)

Melanocortin Receptor (23)

cholecystokinin (23)

PD-1/PD-L1 (23)

DHFR (22)

FXR (22)

Indoleamine 2,3-Dioxygenase (IDO) (22)

SGLT (22)

LPA Receptor (22)

PDK (22)

DYRK (21)

Guanylate cyclase (21)

LRRK2 (21)

Platelet aggregation (21)

Glutathione Peroxidase (20)

MRP (20)

DNA Alkylation (20)

Bradykinin Receptor (20)

OX Receptor (20)

Xanthine Oxidase (20)

Epoxide Hydrolase (20)

Ligand for E3 Ligase (20)

Hydroxylase (20)

YAP (19)

Vasopressin Receptor (19)

c-Myc (18)

GNRH Receptor (18)

PAK (18)

RSV (18)

Aromatase (18)

GTPase (17)

Liver X Receptor (17)

IAP (17)

Ephrin Receptor (17)

ROS Kinase (17)

NOD-like Receptor (NLR) (17)

Myosin (16)

IRE1 (16)

PGE Synthase (16)

PI4K (16)

Antifolate (15)

ABC Transporter (15)

Telomerase (15)

GHSR (15)

Neurotensin Receptor (14)

CSF-1R (14)

LDL (14)

Somatostatin (14)

Lipid (14)

Beta-Secretase (14)

Aminopeptidase (14)

NADPH-oxidase (14)

Monocarboxylate transporter (13)

DNA gyrase (13)

GPCR19 (13)

CaSR (12)

Vitamin (12)

Glutaminase (12)

PAFR (12)

Phosphorylase (12)

Monoamine Transporter (12)

Stearoyl-CoA Desaturase (SCD) (12)

PAI-1 (12)

Acetyl-CoA Carboxylase (12)

Discoidin Domain Receptor (DDR) (12)

Ligands for Target Protein for PROTAC (11)

Arrestin (11)

IFNAR (11)

CETP (11)

NAMPT (11)

IDO (11)

GRK (11)

Isocitrate Dehydrogenase (IDH) (11)

Free radical scavengers (11)

GST (11)

PKM (11)

Melatonin Receptor (10)

UGT (10)

Molecular Glues (10)

Bombesin Receptor (10)

BCRP (10)

OAT (10)

MNK (10)

GPX (10)

MLK (10)

Imidazoline Receptor (10)

Adenylyl Cyclase (9)

Dynamin (9)

LIM Kinase (9)

MT Receptor (9)

ATP Citrate Lyase (9)

Wee1 (9)

PSMA (9)

Porcupine (9)

Neprilysin (9)

SGK (9)

Gap Junction Protein (9)

Apelin receptor (8)

Arginase (8)

Tie-2 (8)

SIK (8)

GlyT (8)

Angiotensin-converting Enzyme (ACE) (8)

PTEN (8)

PAD (8)

ASK (8)

Melanin-concentrating Hormone Receptor (MCHR) (7)

CRM1 (7)

Na+/Ca2+ Exchanger (7)

OCT (7)

AAK1 (7)

PYK2 (7)

Amylase (7)

Annexin A (7)

MAGL (7)

cGAS (7)

CRFR (7)

Methionine Adenosyltransferase (MAT) (7)

Carboxypeptidase (7)

Protease (7)

Oxytocin Receptor (7)

CGRP Receptor (7)

APC/C (7)

p97 (7)

MALT (6)

MyD88 (6)

RAR/RXR (6)

Cell wall (6)

FLAP (6)

Transketolase (6)

Survivin (6)

Decarboxylase (6)

TSH Receptor (6)

Pyroptosis (6)

MELK (6)

CRISPR/Cas9 (6)

Adenosine Deaminase (6)

DAPK (6)

Glyoxalase (6)

DprE1 (5)

TOPK (5)

VDAC (5)

Cell Cycle Arrest (5)

MTH1 (5)

HCN Channel (5)

ACK1 (5)

MRGPR (5)

CD73 (5)

Hippo pathway (5)

Aquaporin (5)

BMI-1 (5)

Advanced Glycation End Products (4)

NPC1L1 (4)

CD38 (4)

NEDD8 (4)

gp120/CD4 (4)

Galectin (4)

Kisspeptin (4)

RANKL/RANK (4)

Adiponectin Receptor (4)

Hexokinase (4)

PROTAC Linker (4)

KSP (4)

Thrombopoietin Receptor (4)

AIM2 (4)

ADC Linker (4)

Transaminase (3)

Necroptosis (3)

Hck (3)

Haspin Kinase (3)

FABP (3)

Na-K-Cl cotransporter (3)

Mucin (3)

OXPHOS (3)

Glutathione reductase (3)

CPT (3)

GluCls (3)

HuR (3)

KLF (3)

Cuproptosis (3)

Taste receptor (2)

GSNOR (2)

NUDIX hydrolase (2)

Piezo Channel (2)

EBI2/GPR183 (2)

Sodium-dependent phosphate transporter (2)

Glutaminyl Cyclase (2)

VDA (2)

FOXO1 (2)

Prolyl Endopeptidase (PREP) (2)

Fas/FasL (2)

PACAP (2)

Integrase (2)

PGC-1α (2)

hCE (2)

RXFP receptor (2)

ATTECs (2)

IGF-2R (2)

Lysosomal Autophagy (2)

Liposome (2)

LYTACs (1)

stilbene oxidase (1)

CYP19A1 (1)

Procollagen C Proteinase (1)

Neuropeptide W (1)

Aconitase (1)

LHRH (1)

N-Acetylglucosaminyltransferase (1)

Stemness kinase (1)

Motilin Receptor (1)

Anion Exchanger (1)

Thioredoxin (1)

Huntingtin (1)

FKBP (1)

Fer/FerT kinase (1)

NMU2R (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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