抗心血管疾病化合物库

Anti-Cardiovascular Disease Compound Library

产品编号： L5400

心血管疾病泛指由于动脉粥样硬化、高脂血症、血液黏稠、高血压等所导致的心脏、大脑及全身组织发生的缺血性或出血性疾病，例如心绞痛、心肌梗塞、中风等，是全球死亡的首要原因。不同类型疾病的发病机制不同，各种抗氧化、抗高血脂、抗缺血、抑制血小板聚集和抗炎物质都具有降低心血管疾病风险的作用。某些天然产物具有抑制粘附分子、细胞因子和趋化因子基因表达，抑制血小板功能，增强内皮细胞一氧化氮释放，抑制平滑肌活化的作用，这些化合物都是心血管疾病药物筛选中的重要工具。

TargetMol 抗心血管疾病化合物库是由 1793 个心血管疾病相关的化合物组成的综合筛选库，用于心血管疾病的相关研究和高通量高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品编号：L5400

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

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产品描述

1793种心血管疾病相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
靶点包括膜转运体、离子通道等心血管疾病相关靶点；
大部分产品是经FDA、EMA或NMPA批准上市的药物，是研究心血管相关疾病的有效工具；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Calcium Channel (172)

PDE (152)

VEGFR (122)

Others (101)

Apoptosis (93)

Autophagy (89)

Sodium Channel (73)

COX (62)

5-HT Receptor (53)

Potassium Channel (46)

AChR (45)

PDGFR (44)

RAAS (43)

Dopamine Receptor (42)

FLT (30)

FGFR (29)

Histone Acetyltransferase (28)

CDK (27)

c-Kit (27)

PARP (26)

Histamine Receptor (25)

PPAR (20)

Antibacterial (19)

Factor Xa (18)

EGFR (17)

TNF (17)

Carbonic Anhydrase (16)

Src (16)

Epigenetic Reader Domain (16)

c-Met/HGFR (15)

IGF-1R (15)

Adenosine Receptor (13)

Thrombin (13)

Parasite (12)

IL Receptor (12)

Norepinephrine (12)

HMG-CoA Reductase (12)

BACE (11)

PKC (11)

JAK (11)

P450 (11)

c-RET (11)

Antibiotic (11)

Mitophagy (10)

TRP/TRPV Channel (10)

Glucocorticoid Receptor (10)

Phospholipase (10)

Ferroptosis (9)

P2Y Receptor (9)

Endogenous Metabolite (9)

p38 MAPK (8)

Bcr-Abl (8)

Guanylate cyclase (8)

Reactive Oxygen Species (8)

Aurora Kinase (8)

HER (8)

Proteasome (7)

ATPase (7)

Integrin (7)

PI3K (7)

GSK-3 (7)

PKA (7)

Serine/threonin kinase (7)

Lipoxygenase (7)

CaMK (7)

Beta-Secretase (7)

P-gp (7)

NF-κB (7)

HIV Protease (6)

Proton pump (6)

Antifungal (6)

Antioxidant (6)

CETP (6)

MRP (6)

Tyrosine Kinases (6)

ROCK (6)

Raf (6)

Drug Metabolite (6)

Interleukin (6)

DNA/RNA Synthesis (6)

Acyltransferase (6)

Prostaglandin Receptor (6)

Acetyl-CoA Carboxylase (6)

Beta Amyloid (6)

HDAC (6)

Hydroxylase (6)

MEK (6)

HIF/HIF Prolyl-Hydroxylase (6)

Serine Protease (5)

Serotonin Transporter (5)

ERK (5)

MAO (5)

Angiotensin-converting Enzyme (ACE) (5)

Akt (5)

Trk receptor (5)

Influenza Virus (5)

c-Fms (5)

GABA Receptor (5)

Chloride channel (4)

Dehydrogenase (4)

NADPH (4)

Tie-2 (4)

Glutathione Peroxidase (4)

Nucleoside Antimetabolite/Analog (4)

Liver X Receptor (4)

iGluR (4)

NMDAR (4)

ROS (4)

DPP-4 (4)

Chk (4)

Epoxide Hydrolase (4)

GluR (4)

SARS-CoV (4)

Ephrin Receptor (4)

AMPK (4)

Syk (4)

NOD (4)

Sigma receptor (4)

TAM Receptor (4)

DNA Alkylator/Crosslinker (3)

Virus Protease (3)

Antifolate (3)

CSF-1R (3)

Topoisomerase (3)

Myosin (3)

LDL (3)

P2X Receptor (3)

Na-K-Cl cotransporter (3)

Mitochondrial Metabolism (3)

Opioid Receptor (3)

HCN Channel (3)

DNA Alkylation (3)

Endothelin Receptor (3)

ALK (3)

RSV (3)

IκB/IKK (3)

Neprilysin (3)

HIF (3)

SGK (3)

S6 Kinase (3)

Protease-activated Receptor (3)

FAK (3)

Imidazoline Receptor (3)

Monoamine Oxidase (3)

Thyroid hormone receptor(THR) (2)

Histone Methyltransferase (2)

HCV Protease (2)

Estrogen/progestogen Receptor (2)

LTR (2)

Na+/Ca2+ Exchanger (2)

Histone Demethylase (2)

HBV (2)

Rho (2)

FXR (2)

Leukotriene Receptor (2)

PYK2 (2)

Vitamin (2)

Fatty Acid Synthase (2)

FAAH (2)

HSV (2)

Xanthine Oxidase (2)

Androgen Receptor (2)

mTOR (2)

PGE Synthase (2)

MAPK (2)

Sirtuin (2)

Nrf2 (2)

PAI-1 (2)

STAT (2)

GPR (2)

PDK (2)

Gap Junction Protein (2)

NADPH-oxidase (2)

DNA Methyltransferase (2)

Tyrosinase (2)

AhR (2)

NOD-like Receptor (NLR) (2)

MLK (2)

NO Synthase (2)

Adenylyl cyclase (1)

Transferase (1)

NPC1L1 (1)

Monocarboxylate transporter (1)

DHFR (1)

ROR (1)

DNA-PK (1)

DprE1 (1)

YAP (1)

IFNAR (1)

PERK (1)

JNK (1)

TOPK (1)

Phosphatase (1)

Progesterone Receptor (1)

N-Acetylglucosaminyltransferase (1)

Estrogen Receptor/ERR (1)

Wnt/beta-catenin (1)

VDAC (1)

Pim (1)

Cysteine Protease (1)

Neurotensin Receptor (1)

NAMPT (1)

Caspase (1)

IRE1 (1)

Annexin A (1)

FLAP (1)

E1/E2/E3 Enzyme (1)

RIP kinase (1)

UGT (1)

GRK (1)

GlyT (1)

BTK (1)

Antifection (1)

Anion Exchanger (1)

Isocitrate Dehydrogenase (IDH) (1)

CCR (1)

Vasopressin Receptor (1)

ACK (1)

cAMP (1)

Thrombopoietin Receptor (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

ATP Citrate Lyase (1)

BCRP (1)

AChE (1)

Antiviral (1)

LRRK2 (1)

Aminopeptidase (1)

ASK (1)

Casein Kinase (1)

GST (1)

Reverse Transcriptase (1)

CRISPR/Cas9 (1)

RXFP receptor (1)

PLK (1)

Cannabinoid Receptor (1)

Discoidin Domain Receptor (DDR) (1)

DAPK (1)

Platelet aggregation (1)

Anti-infection (1)

Ras (1)

Microtubule Associated (1)

p97 (1)

CFTR (1)

p53 (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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